The Essential Thrombocythemia, Thrombotic Risk Stratification, and Cardiovascular Risk Factors

Evaluating new cardiovascular risk factors for risk stratification.

The expression pattern of c-mpl in megakaryocytes correlates with thrombotic risk in essential thrombocythemia.

Using immunohistochemistry, we investigated the expression of c-mpl in bone marrow megakaryocytes of 88 patients with essential thrombocythemia (ET), 6 patients with secondary thrombocytosis (ST), and 20 patients with lymphoma (controls). Considering both the pattern of expression and the staining intensity, we identified a uniform and a heterogeneous pattern of c-mpl expression. The uniform pa...

Recent Advance in Diagnosis, Pathogenesis and Risk Stratification of Essential Thrombocythemia

In the 2016 version of WHO classification, bone marrow morphology is critical in the distinction between ET and pre-PMF. Reticulin-fiber grading becomes central: grade 1 or less is needed for ET. Furthermore, CALR assessment must be performed in all ET patients without JAK2 mutation. Some prognostic implications have been described for CALR mutations, i.e., a lower risk of thrombosis in ET. Abb...

Thrombotic risk assessment in 185 WHO-defined essential thrombocythemia patients: single center experience

Thrombosis risk in essential thrombocythemia (ET) patients can be assessed using different prognostic systems. Conventional risk factors include age more than 60 years and history of previous thrombosis. In addition, other factors such as JAK2 V617F mutations, cardiovascular risk factors, leukocytosis more than 11 × 10(9)/l, thrombophilic factors and platelet count more than 1500 × 10(9)/l are ...

The effects of cinnamon on risk factors of cardiovascular disease

Introduction: Herbal medicine is being considered today due to the side effects and high prices of chemical medicines. Cinnamon appears to be effective in the prevention and treatment of a variety of diseases, both as a food spice and in traditional medicine. We attempted to collect the effects of cinnamon on the occurrence of cardiovascular disorders and their related parameters in this review...